We are looking for:

Postdoc in T-cell development

The Institute of Laboratory Animal Science, group of Prof. Buch, offers a postdoctoral position (2 years) with a focus on T-cell development. The group is working on how T-cell tolerance is built up and how and why it is broken in autoimmune diseases.


The project

During T-cell development there is a first important checkpoint, negative selection, which is important for tolerance induction. To investigate and to gain a deeper understanding of this process, new mouse models (conditional as well as crispered mice) will be used in the project. In addition, a series of studies will be undertaken on cell lines which show negative selection. During the project not only basic immunological methods but also high parameter assays (Cytof, Symphony, RNAseq) and the latest screening methods (CRISPR/Cas9-based) can be applied. The models and methods are established, and primary data support the entry into the project. The project can and should develop with the interests of the postdoctoral fellow.


Profile of postdoctoral student

• Degree and doctorate in biology, biochemistry, biomedicine, medicine or

  equivalent with an immunological focus

• Deep immunological understanding and interest in T cells

• Experience in flow cytometry, cell culture and molecular biology

• Experience in work with animals

• Ability to work independently

• Good English skills


We offer

Work in a young dynamic team at the biotech location Schlieren on the outskirts of Zurich. The projects at the institute include not only basic research but also translational research as well as the further path to spinning off a company. This leads to an interesting and exciting environment. The salary is internationally competitive, with excellent social benefits. Training, e.g. in the animal experiment courses offered by the institute and through the various core facilities (FACS, microscopy, genomics), supports the candidate in his/her development. Presentation of results at national and international conferences is ensured. Zurich is regularly found in the top 10 of cities with the highest quality of life worldwide.

The application

The application should include a CV, letter of motivation, list of publications and a letter of reference.

It should be sent as a single PDF until 31.1.2019 to brigitte.egli@uzh.ch

The position starts 01. Feb. 2019, possibly earlier.

Further information can be obtained from Prof. Buch at thorsten.buch@uzh.ch