This two days course provides the participants with theoretical knowledge and tools for generation of gene-modified animals.
Participants of the course will learn:
- The different techniques for generation of gene-modified animals in small rodents and large animals: Conventional Transgenes, ES cell-Technology, Cre-loxP system, gene editing, and cloning
- Practical considerations for planning transgenes and gene targetings
- Practical considerations for conducting CRISPR/Cas9-mediated gene editing
- All planning steps required for generating a new gene-modified animal
- Reproductive aspects of generation of gene-modified animals
- Ethical and 3R aspects of generation and maintenance of gene-modified animals
- Nomenclature and reproducibility in the context of work with gene-modified animals
- Legal requirements of generation and maintenance of gene-modified animals
After lectures introducing the basics in these topics participants solve practical problems typically arising during the course of a project involving generation of new gene-modified animal (internally or externally). The solutions will be discussed.
Participants of the course will be able to plan a new gene-modification with a specific scientific purpose and supervise/control the work of a transgenic facility or external service provider.
This course is addressing PhD students, post-docs and senior researchers.
Other relevant courses: Module 5E and Module 15E
For more details, please read the full description of this course in this link.
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